cEt-BNA
DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite
Quick view. We supply DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite as a constrained ethyl BNA phosphoramidite for high-affinity therapeutic oligonucleotide synthesis. CAS 1197033-19-4. Catalog target purity: Specification on request.
Product profile
DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite is classified as protected oligonucleotide phosphoramidite building block (Formula C49H54N7O8P; molecular weight 899.97).
DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite — 5'-ODMT cEt N-Bz A Phosphoramidite Amidite is a locked nucleic acid (LNA) analogue. 5'-ODMT cEt N-Bz A Phosphoramidite Amidite possesses hybridization and mismatch discrimination attributes similar to those of LNA and shows resistance to exonuclease digestion.
For DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite, form: Solid.
Names and search terms
Confirmed or normalized name variants
- S-cEt-A phosphoramidite
- N6-Bz-2'-O-4'-A-Locked-Ar-CET-Phosphoramidite
- 9-(2,5-Anhydro-4-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3-O-{(2-cyanoethoxy)[di(propan-2-yl)amino]phosphanyl}-6-deoxy-alpha-L-mannofuranosyl)-N-benzoyl-9H-purin-6-amine
- DMT-S-cEt-rA(Bz)-3'-CE-Phosphoramidite
- DMTr-S-cEt-rA(Bz)-3'-2-cyanoethyl phosphoramidite
Useful catalog search terms
- CAS 1197033-19-4
- Protected oligonucleotide phosphoramidite building block
- DMTr/DMT protection
- conformationally locked sugar
- phosphoramidite coupling group
- cEt-BNA
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; conformationally locked sugar; phosphoramidite coupling group |
|---|---|
| Form | Solid |
| Color | White to off-white |
| InChI | InChI=1S/C49H54N7O8P/c1-32(2)56(33(3)4)65(61-28-14-27-50)64-43-42-47(55-31-53-41-44(51-30-52-45(41)55)54-46(57)35-15-10-8-11-16-35)63-48(43,34(5)62-42)29-60-49(36-17-12-9-13-18-36,37-19-23-39(58-6)24-20-37)38-21-25-40(59-7)26-22-38/h8-13,15-26,30-34,42-43,47H,14,28-29H2,1-7H3,(H,51,52,54,57)/t34-,42+,43-,47+,48-,65?/m0/s |
| InChIKey | XHEVZGBLRSIPCO-DZGFXGBPSA-N |
| SMILES | COc1ccc(C(OC[C@]23O[C@@H](n4cnc5c(NC(=O)c6ccccc6)ncnc54)[C@H](O[C@H]2C)[C@@H]3OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite can be evaluated as a monomer or functional building block in solid-phase oligonucleotide synthesis.
- Typical development work includes coupling-condition screening, deprotection compatibility checks and LC-MS/HPLC characterization of test sequences.
- The material can also support related-analog comparison, impurity-reference preparation and route-development studies.
Product-specific evaluation notes
Potential advantages
- Locked/bicyclic sugar motifs can substantially increase duplex thermal stability and mismatch discrimination.
Method limitations
- High-affinity monomers require careful positional design; over-substitution may increase off-target binding or complicate synthesis.
These points describe DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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Frequently asked questions
Can the package size for DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CB-0004 and CAS 1197033-19-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss DMTr-S-cEt-rA(Bz)-3'-CE-Phosphoramidite or the named structural feature represented by this product.