Modified Nucleosides
N,N-dimethyl-2'-O-methylcytidine
Quick view. We supply N,N-dimethyl-2'-O-methylcytidine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 34218-81-0. Catalog target purity: Specification on request.
Product profile
N,N-dimethyl-2'-O-methylcytidine is classified as nucleoside or protected nucleoside intermediate (Formula C12H19N3O5; molecular weight 285.3).
N,N-dimethyl-2'-O-methylcytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For N,N-dimethyl-2'-O-methylcytidine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N(4),N(4),O(2')-Trimethylcytidine
- N4,N4,2'-O-TriMethylcytidine
- Cytidine, N,N-dimethyl-2'-O-methyl-
- N,N-Dimethyl-2’-O-methylcytidine, RNA modified nucleoside m4-2C
Useful catalog search terms
- CAS 34218-81-0
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Modified Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| InChI | InChI=1S/C12H19N3O5/c1-14(2)8-4-5-15(12(18)13-8)11-10(19-3)9(17)7(6-16)20-11/h4-5,7,9-11,16-17H,6H2,1-3H3/t7-,9-,10-,11-/m1/s |
| InChIKey | WFCJCYSSTXNUED-QCNRFFRDSA-N |
| SMILES | CN(C)C1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC |
| Boiling point | 470.7±55.0 °C(Predicted) |
| Density | 1.44±0.1 g/cm3(Predicted) |
| pKa | 13.37±0.70(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N,N-dimethyl-2'-O-methylcytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N,N-dimethyl-2'-O-methylcytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0799 and CAS 34218-81-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry.