2'-O-Me Nucleosides
N2-Dimethylformamidine-2'-O-methylguanosine
Quick view. N2-Dimethylformamidine-2'-O-methylguanosine is an N2-protected, 2'-O-methyl guanosine building block for nucleic-acid synthesis research. CAS 183737-04-4. Catalog target purity: ≥97%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N2-Dimethylformamidine-2'-O-methylguanosine is classified as 2'-o-me nucleosides (Formula C14H20N6O5; molecular weight 352.35).
N2-Dimethylformamidine-2'-O-methylguanosine — Protected 2'-O-methyl guanosine building block for nucleic-acid synthesis research.
For N2-Dimethylformamidine-2'-O-methylguanosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N2-DMF-2'-O-methylguanosine
- N2-dmf-2'-OMe-G
- N2-DMF-2'-OMe-rG
- N2-[(dimethylamino)methylidene]-2'-O-methyl-D-guanosine
Useful catalog search terms
- CAS 183737-04-4
Physicochemical data
| InChIKey | KDQQTCFKBCWYFL-QYVSTXNMSA-N |
|---|---|
| Base protection | N2-dimethylformamidine |
| Sugar modification | 2'-O-methyl |
| Physical form | White, off-white to faint yellow powder |
| Storage temperature | 2-8 C |
| PubChem CID | 136119103 |
| InChI | InChI=1S/C14H20N6O5/c1-19(2)5-16-14-17-11-8(12(23)18-14)15-6-20(11)13-10(24-3)9(22)7(4-21)25-13/h5-7,9-10,13,21-22H,4H2,1-3H3,(H,17,18,23)/t7-,9-,10-,13-/m1/s1 |
| SMILES | CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N2-Dimethylformamidine-2'-O-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N2-Dimethylformamidine-2'-O-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0809 and CAS 183737-04-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.