Protected Nucleosides
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine
Quick view. Guanosine derivative bearing N2-isobutyryl and 5'-O-dimethoxytrityl protection plus a 3'-O-(2-methoxyethyl) substituent, with a free 2'-hydroxyl group. CAS 256224-05-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine is classified as protected nucleosides (Formula C38H43N5O9; molecular weight 713.79 g/mol).
N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(methoxyethyl)guanosine
Useful catalog search terms
- 256224-05-2
Physicochemical data
| Systematic name | N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-hydroxy-4-(2-methoxyethoxy)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide |
|---|---|
| Chemical form | Neutral N2-isobutyryl, 5'-O-DMTr-protected, 3'-O-MOE-modified guanosine |
| Structural scope | N2-isobutyryl, 5'-O-DMTr and 3'-O-(2-methoxyethyl) substitution with a free 2'-hydroxyl |
| Stereochemical scope | Four defined ribose stereocenters |
| InChIKey | GORMIDFTGJPHPL-BEGXHNNXSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)guanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0366 and CAS 256224-05-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.