Protected Nucleosides
N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine
Quick view. An N4-benzoyl- and 5'-O-DMTr-protected 2',2'-difluoro-2'-deoxycytidine derivative, CAS 142808-43-3. CAS 142808-43-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine is classified as protected nucleosides (Formula C37H33F2N3O7; molecular weight 669.67).
N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine — A doubly protected 2',2'-difluoro-2'-deoxycytidine intermediate for research use in nucleoside synthesis.
For N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N4-Benzoyl-2'-deoxy-5'-O-DMTr-2',2'-difluorocytidine
- N4-Bz-5'-O-DMTr-2',2'-diF-dC
Useful catalog search terms
- 142808-43-3
Physicochemical data
| Systematic name | N-(1-((2R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,3-difluoro-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide |
|---|---|
| SMILES | COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4[C@H](C([C@@H](O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)(F)F)O |
| Nucleoside core | 2',2'-Difluoro-2'-deoxycytidine |
| Base protection | N4-Benzoyl |
| 5' protection | DMTr |
| Hydroxyl state | Free 3'-OH |
| PubChem CID | 121300044 |
| InChIKey | WTSBHVUMDHCRKO-LIAFXSCVSA-N |
| InChI | InChI=1S/C37H33F2N3O7/c1-46-28-17-13-26(14-18-28)36(25-11-7-4-8-12-25,27-15-19-29(47-2)20-16-27)48-23-30-32(43)37(38,39)34(49-30)42-22-21-31(41-35(42)45)40-33(44)24-9-5-3-6-10-24/h3-22,30,32,34,43H,23H2,1-2H3,(H,40,41,44,45)/t30-,32-,34-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N4-Benzoyl-5'-O-DMTr-2',2'-difluoro-2'-deoxycytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0153 and CAS 142808-43-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.