2'-O-Me Nucleosides
N4-Methyl-2'-O-methyl-cytidine
Quick view. We supply N4-Methyl-2'-O-methyl-cytidine as a 2'-O-methyl nucleoside for modified RNA monomer, nucleotide and analytical standard workflows. CAS 13048-95-8. Catalog target purity: Specification on request.
Product profile
N4-Methyl-2'-O-methyl-cytidine is classified as nucleoside or protected nucleoside intermediate (Formula C11H17N3O5; molecular weight 271.27).
N4-Methyl-2'-O-methyl-cytidine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For N4-Methyl-2'-O-methyl-cytidine, reported solubility: Aqueous Base (Slightly), DMSO (Slightly), Water (Slightly). Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere.
Names and search terms
Confirmed or normalized name variants
- N(4), O(2')-Dimethylcytidine
- N,2'-O-Dimethylcytidine
- N4,2'-O-dimethylcytidine
- Cytidine, N-methyl-2'-O-methyl-
- N4-Methyl-2’-O-methyl-cytidine, N4,O2’-Dimethyl cytidine
- N4-Methyl-2’-O-methyl-cytidine,N4,O2’-Dimethyl cytidine,RNA-modified nucleoside m4Cm
Useful catalog search terms
- CAS 13048-95-8
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- 2'-O-Me Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| InChI | InChI=1S/C11H17N3O5/c1-12-7-3-4-14(11(17)13-7)10-9(18-2)8(16)6(5-15)19-10/h3-4,6,8-10,15-16H,5H2,1-2H3,(H,12,13,17)/t6-,8-,9-,10-/m1/s |
| InChIKey | BNXGRQLXOMSOMV-PEBGCTIMSA-N |
| SMILES | CNC1=NC(=O)N(C=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)OC |
| Melting point | 203 - 205°C |
| Boiling point | 475.4±55.0 °C(Predicted) |
| Density | 1.54±0.1 g/cm3(Predicted) |
| pKa | 13.37±0.70(Predicted) |
| Form | Solid |
| Color | White to Off-White |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N4-Methyl-2'-O-methyl-cytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N4-Methyl-2'-O-methyl-cytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0013 and CAS 13048-95-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry.