2'-O-Me Nucleosides
N6-Benzoyl-2'-O-methyl-3'-O-(t-butyldimethylsilyl) adenosine
Quick view. A 3'-O-TBDMS-protected N6-benzoyl-2'-O-methyladenosine intermediate for research involving modified oligonucleotide synthesis. CAS 454424-09-0. Catalog target purity: 99.98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N6-Benzoyl-2'-O-methyl-3'-O-(t-butyldimethylsilyl) adenosine is classified as 2'-o-me nucleosides (Formula C24H33N5O5Si; molecular weight 499.60).
N6-Benzoyl-2'-O-methyl-3'-O-(t-butyldimethylsilyl) adenosine — Research intermediate for modified oligonucleotide or related nucleic-acid synthesis
For N6-Benzoyl-2'-O-methyl-3'-O-(t-butyldimethylsilyl) adenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 3'-O-TBDMS-2'-O-Me-rA(Bz)
- 3'-TBS-OMe-Bz-rA
- HY-W1008069
- TSW-01146
- NS088
Useful catalog search terms
- 454424-09-0
Physicochemical data
| Modification | N6-benzoyl; 2'-O-methyl; 3'-O-TBDMS |
|---|---|
| SMILES | OC[C@H]1O[C@@H](N(C=N2)C3=C2C(NC(C4=CC=CC=C4)=O)=NC=N3)[C@H](OC)[C@@H]1O[Si](C(C)(C)C)(C)C |
| PubChem CID | 169448809 |
| InChI | InChI=1S/C24H33N5O5Si/c1-24(2,3)35(5,6)34-18-16(12-30)33-23(19(18)32-4)29-14-27-17-20(25-13-26-21(17)29)28-22(31)15-10-8-7-9-11-15/h7-11,13-14,16,18-19,23,30H,12H2,1-6H3,(H,25,26,28,31)/t16-,18-,19-,23-/m1/s1 |
| InChIKey | ROHHXNDVYNHGRQ-DYVMYPEFSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N6-Benzoyl-2'-O-methyl-3'-O-(t-butyldimethylsilyl) adenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N6-Benzoyl-2'-O-methyl-3'-O-(t-butyldimethylsilyl) adenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2OMN-0138 and CAS 454424-09-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.