Modified Nucleosides
N6-Methyl-3'-O-methyladenosine
Quick view. A dual-modified adenosine bearing N6-methyl and 3'-O-methyl substitution for modified-nucleoside and oligonucleotide research. CAS 60037-52-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N6-Methyl-3'-O-methyladenosine is classified as modified nucleosides (Formula C12H17N5O4; molecular weight 295.29).
N6-Methyl-3'-O-methyladenosine — Modified adenosine building block or analytical reference for nucleoside and oligonucleotide research
For N6-Methyl-3'-O-methyladenosine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- N6,3'-O-Dimethyladenosine
- N6,O3'-Dimethyladenosine
- BRP-02452
Useful catalog search terms
- 60037-52-7
Physicochemical data
| Modification | N6-methyl; 3'-O-methyl |
|---|---|
| Physical form | White or off-white solid |
| Storage temperature | 2-8 C |
| InChIKey | VFAAIVDBAJHYRM-WOUKDFQISA-N |
| SMILES | CNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)OC)O |
| PubChem CID | 170275496 |
| InChI | InChI=1S/C12H17N5O4/c1-13-10-7-11(15-4-14-10)17(5-16-7)12-8(19)9(20-2)6(3-18)21-12/h4-6,8-9,12,18-19H,3H2,1-2H3,(H,13,14,15)/t6-,8-,9-,12-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe N6-Methyl-3'-O-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N6-Methyl-3'-O-methyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0811 and CAS 60037-52-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.