Modified Nucleosides
N6,N6-Dimethyl-2'-O-methyladenosine
Quick view. A stereodefined adenosine derivative bearing N6,N6-dimethyl and 2'-O-methyl modifications with free 3'- and 5'-hydroxyl groups, CAS 30891-53-3. CAS 30891-53-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N6,N6-Dimethyl-2'-O-methyladenosine is classified as modified nucleosides (Formula C13H19N5O4; molecular weight 309.32 g/mol).
N6,N6-Dimethyl-2'-O-methyladenosine — Base- and sugar-methylated adenosine building block for modified nucleoside and RNA chemistry.
For N6,N6-Dimethyl-2'-O-methyladenosine, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N,N-Dimethyl-2'-O-methyladenosine
- N6,N6,2'-O-trimethyladenosine
- O2'-methyl-N6,N6-dimethyladenosine
Useful catalog search terms
- 30891-53-3
- PubChem CID 20722670
- IPRQAJTUSRLECG-QYVSTXNMSA-N
Physicochemical data
| PubChem CID | 20722670 |
|---|---|
| IUPAC name | (2R,3R,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-2-(hydroxymethyl)-4-methoxyoxolan-3-ol |
| InChIKey | IPRQAJTUSRLECG-QYVSTXNMSA-N |
| InChI | InChI=1S/C13H19N5O4/c1-17(2)11-8-12(15-5-14-11)18(6-16-8)13-10(21-3)9(20)7(4-19)22-13/h5-7,9-10,13,19-20H,4H2,1-3H3/t7-,9-,10-,13-/m1/s1 |
| SMILES | CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OC |
| Stereochemistry | (2R,3R,4R,5R) ribofuranose system |
| Nucleoside modifications | N6,N6-dimethyl; 2'-O-methyl |
| Free hydroxyls | 3'-OH and 5'-OH |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Reference compound for chemical identity studies involving N6,N6-dimethyl-2'-O-methyladenosine.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe N6,N6-Dimethyl-2'-O-methyladenosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N6,N6-Dimethyl-2'-O-methyladenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0798 and CAS 30891-53-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.