Modified Nucleosides
5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine
Quick view. 5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine is a C5-substituted modified deoxyuridine with CAS 115794-55-3. CAS 115794-55-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of 5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine](/structures/5af95e1e7cd3f590.svg)
Product profile
5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine is classified as c5-substituted modified deoxyuridine (Formula C14H16F3N3O6; molecular weight 379.29).
5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- TFA-AA-dU
- 5-TFA-aa-2'-dU
- TFA-AA-2'-deoxyuridine
- ChemicalBook CB92454305
Useful catalog search terms
- CAS 115794-55-3
Physicochemical data
| Systematic name | 2,2,2-Trifluoro-N-((E)-3-(1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)allyl)acetamide |
|---|---|
| Structural feature | Trifluoroacetyl-protected aminoallyl substituent with E geometry |
| PubChem CID | 10959831 |
| InChI | InChI=1S/C14H16F3N3O6/c15-14(16,17)12(24)18-3-1-2-7-5-20(13(25)19-11(7)23)10-4-8(22)9(6-21)26-10/h1-2,5,8-10,21-22H,3-4,6H2,(H,18,24)(H,19,23,25)/b2-1+/t8-,9+,10+/m0/s1 |
| InChIKey | MBPYSSRDTGXWJD-HFVMFMDWSA-N |
| SMILES | C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)/C=C/CNC(=O)C(F)(F)F)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-[3-(Trifluoroacetamido)-E-1-propenyl]-2'-deoxyuridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0214 and CAS 115794-55-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Modified Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.