2'-FANA Nucleosides
2'-Deoxy-2'-fluoro-5-ethyl-arabinouridine
Quick view. We supply 2'-Deoxy-2'-fluoro-5-ethyl-arabinouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 83546-42-3. Catalog target purity: Specification on request.
Product profile
2'-Deoxy-2'-fluoro-5-ethyl-arabinouridine is classified as nucleoside or protected nucleoside intermediate (Formula C11H15FN2O5; molecular weight 274.25).
2'-Deoxy-2'-fluoro-5-ethyl-arabinouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-Deoxy-2'-fluoro-5-ethyl-arabinouridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-Fluoro-5-ethylarabinosyluracil
- 2'-Fluoro-5-ethyl-beta-D-arabinofuranosyluracil
- 5-Ethyl-2'-deoxy-2'-fluoro-beta-D-arabinouridine
- 1-(2-deoxy-2-fluoroarabinofuranosyl)-5-ethyluracil
- 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyl-
Useful catalog search terms
- CAS 83546-42-3
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-FANA Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1S/C11H15FN2O5/c1-2-5-3-14(11(18)13-9(5)17)10-7(12)8(16)6(4-15)19-10/h,6-8,10,15-16H,2,4H2,1H3,(H,13,17,18)/t6-,7+,8-,10-/m1/s |
| InChIKey | SWFJAJRDLUUIOA-IBCQBUCCSA-N |
| SMILES | CCC1=CN(C(=O)NC1=O)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-5-ethyl-arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-2'-fluoro-5-ethyl-arabinouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAN-0079 and CAS 83546-42-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-Deoxy-2'-fluoro-5-ethyl-arabinouridine or the named structural feature represented by this product.