2'-FANA Nucleosides
2'-FANA-dA
Quick view. We supply 2'-FANA-dA as a 2'-fluoro-arabino adenosine nucleoside for FANA monomer synthesis and modified oligonucleotide research. CAS 20227-41-2. Catalog target purity: Specification on request.
Product profile
2'-FANA-dA is classified as nucleoside or protected nucleoside intermediate (Formula C10H12FN5O3; molecular weight 269.23).
2'-FANA-dA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-FANA-dA, form: Solid.
Names and search terms
Confirmed or normalized name variants
- 2'-FANA-Ar
- Ara-2'-F-2'-dA
- -4-fluoro-2-(hydroxymethyl)
- 2'-Deoxy-2'-fluoroarabinoadenosine
- 2'-Deoxy-2'-fluoro-beta-D-arabinoadenosine
- 6-AMino-purine-2'-fluoro-2'-deoxy arabineoside
- 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine
- 9-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)adenine
Useful catalog search terms
- CAS 20227-41-2
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-FANA Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| Melting point | 233-234 °C |
| Boiling point | 628.6±65.0 °C(Predicted) |
| Density | 2.01 |
| pKa | 12.60±0.70(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | [C@H]1(O)[C@H](F)[C@@H](O[C@@H]1CO)N1C2N=CN=C(N)C=2N=C1 |&1:0,2,4,6,r| |
| InChI | InChI=1/C10H12FN5O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5+,7-,10-/s |
| InChIKey | ZGYYPTJWJBEXBC-VNCZOPGJNA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-FANA-dA or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-FANA-dA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0161 and CAS 20227-41-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 2'-FANA-dA or the named structural feature represented by this product.