Protected Nucleosides
3'-O-TBDMS-2'-O-Me-rA(Bz)
Quick view. We supply 3'-O-TBDMS-2'-O-Me-rA(Bz) as a protected 2'-O-methyl adenosine intermediate used in the preparation of RNA synthesis building blocks. CAS 454424-09-0. Catalog target purity: Specification on request.
Product profile
3'-O-TBDMS-2'-O-Me-rA(Bz) is classified as nucleoside or protected nucleoside intermediate.
3'-O-TBDMS-2'-O-Me-rA(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 3'-O-TBDMS-2'-O-Me-rA(Bz), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Useful catalog search terms
- CAS 454424-09-0
- Nucleoside or protected nucleoside intermediate
- TBDMS protection
- 2'-O-methyl modification
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | TBDMS protection; 2'-O-methyl modification |
|---|
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-O-TBDMS-2'-O-Me-rA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 3'-O-TBDMS-2'-O-Me-rA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0072 and CAS 454424-09-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.