2'-FANA Nucleosides
5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinouridine
Quick view. We supply 5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinouridine as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 69123-98-4. Catalog target purity: Specification on request.
Product profile
5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinouridine is classified as nucleoside or protected nucleoside intermediate (Formula C9H10FIN2O5; molecular weight 372.09).
5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinouridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinouridine, reported solubility: DMSO: soluble at 5mg/mL, clear (warmed). Storage: Refrigerator.
Names and search terms
Confirmed or normalized name variants
- fialuridine
- FIAU
- NSC 678514
- 5-I-2'-F-dU
- Fialuridine(FIAU)
- Fluoroiodoarauracil
- 2'-FLUORO-5-IODOURACIL
- 5-Iodo-2'-fluoroarauracil
Useful catalog search terms
- CAS 69123-98-4
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-FANA Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h,4-6,8,14-15H,2H2,(H,12,16,17)/t4-,5+,6-,8-/s |
| InChIKey | IPVFGAYTKQKGBM-BYPJNBLXSA-N |
| SMILES | [C@H]1(O[C@H](CO)[C@@H](O)[C@@H]1F)N1C=C(C(=O)NC1=O)I |&1:0,2,5,7,r| |
| Melting point | 216-217°C |
| Density | 2.18±0.1 g/cm3(Predicted) |
| pKa | 7.94±0.10(Predicted) |
| Form | powder |
| Color | white to beige |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAN-0075 and CAS 69123-98-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinouridine or the named structural feature represented by this product.