Protected Nucleosides
5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine
Quick view. We supply 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine as a protected dideoxy nucleoside intermediate for chain-terminator, analog and modified nucleotide synthesis. CAS 42867-74-3. Catalog target purity: Specification on request.
Product profile
5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine is classified as nucleoside or protected nucleoside intermediate (Formula C11H12N2O5; molecular weight 252.22).
5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- SCHEMBL1879258
- ZJEYZGAQPYLRFC-WCBMZHEXSA-N
- Uridine, 2',3'-didehydro-2',3'-dideoxy-, 5'-acetate
Useful catalog search terms
- CAS 42867-74-3
- Nucleoside or protected nucleoside intermediate
- Protected Nucleosides
Physicochemical data
| InChI | InChI=1S/C11H12N2O5/c1-7(14)17-6-8-2-3-10(18-8)13-5-4-9(15)12-11(13)16/h2-5,8,10H,6H2,1H3,(H,12,15,16)/t8-,10+/m0/s |
|---|---|
| InChIKey | ZJEYZGAQPYLRFC-WCBMZHEXSA-N |
| SMILES | CC(=O)OC[C@@H]1C=C[C@@H](O1)N2C=CC(=O)NC2=O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-Acetyl-2',3'-dideoxy-2',3'-didehydro-uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0244 and CAS 42867-74-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.