Protected Nucleosides
5'-O-DMTr-N6-methyl-2'-deoxyadenosine
Quick view. We supply 5'-O-DMTr-N6-methyl-2'-deoxyadenosine as a DMTr-protected nucleoside intermediate for selective oligonucleotide building-block synthesis. CAS 98056-69-0. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-N6-methyl-2'-deoxyadenosine is classified as nucleoside or protected nucleoside intermediate (Formula C32H33N5O5; molecular weight 567.63).
5'-O-DMTr-N6-methyl-2'-deoxyadenosine — 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-methyladenosine is a 5’-O-(4,4'-Dimethoxytriphenylmethy) substitued derivative of the 2’-deoxy N-methyl analogue of Adenosine. It is used in the preparation of oligonucleotides containing N6-methyladenine residues in the GATC site.
For 5'-O-DMTr-N6-methyl-2'-deoxyadenosine, reported solubility: DMSO: 100 mg/mL (176.17 mM; Need ultrasonic). Storage: 4°C, away from moisture and light.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMT-N6-methyl-2'-deoxyadenosine
- N6-Me-DMT-dA
- -5-(6-(methylamino)
- 5'-O-DMT-N6-Me-2'-dA
- 5'-DMT-N6-Methyl-2'-dA
- N6-ME-DMT-DEOXYADENOSINE
- 2'-Deoxy-5'-O-DMT-N6-methyladenosine
- 5'-O-DMT-2'-deoxy-N-Methyl-adenosine
Useful catalog search terms
- CAS 98056-69-0
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- Protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection |
|---|---|
| InChI | InChI=1S/C32H33N5O5/c1-33-30-29-31(35-19-34-30)37(20-36-29)28-17-26(38)27(42-28)18-41-32(21-7-5-4-6-8-21,22-9-13-24(39-2)14-10-22)23-11-15-25(40-3)16-12-23/h4-16,19-20,26-28,38H,17-18H2,1-3H3,(H,33,34,35)/t26-,27+,28+/m0/s |
| InChIKey | OKZZBPBWGABLJR-UPRLRBBYSA-N |
| SMILES | CNC1=C2C(=NC=N1)N(C=N2)[C@H]3C[C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O |
| Boiling point | 782.9±70.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| pKa | 13.75±0.60(Predicted) |
| Form | Solid |
| Color | Off-white to light yellow |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-N6-methyl-2'-deoxyadenosine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
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Frequently asked questions
Can the package size for 5'-O-DMTr-N6-methyl-2'-deoxyadenosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0315 and CAS 98056-69-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Protected Nucleosides product family and its named chemistry.