2'-FANA Nucleosides
6-Amino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside
Quick view. We supply 6-Amino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside as a specialty product for nucleic acid chemistry and oligonucleotide research workflows. CAS 123318-82-1. Catalog target purity: Specification on request.
Product profile
6-Amino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside is classified as nucleoside or protected nucleoside intermediate (Formula C10H11ClFN5O3; molecular weight 303.68).
6-Amino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 6-Amino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside, reported solubility: DMSO: >10mg/mL. Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- clofarabine
- 2-CHLORO-2'-ARABINOFLUORO-2'-DEOXYADENOSINE
- 5-(6-amino-2-chloro-purin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- CAFDA
- 2-chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine
- 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amin
- 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)adenine
- Clolar
Useful catalog search terms
- CAS 123318-82-1
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- amine functionality
- 2'-FANA Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification; amine functionality |
|---|---|
| InChI | InChI=1/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/s |
| InChIKey | INHHKRVRRUIAPA-KJHIFWANSA-N |
| SMILES | C12N=C(N=C(N)C=1N=CN2[C@H]1[C@@H](F)[C@H](O)[C@@H](CO)O1)Cl |&1:10,11,13,15,r| |
| Melting point | 228-2310C |
| Boiling point | 550.0±60.0 °C(Predicted) |
| Density | 1.4804 (estimate) |
| pKa | 12.56±0.70(Predicted) |
| Form | Powder |
| Color | white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 6-Amino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 6-Amino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FAN-0012 and CAS 123318-82-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss 6-Amino-2-chloropurine-9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside or the named structural feature represented by this product.