Base-protected Nucleosides
2',3'-dideoxy-C(Ac)
Quick view. 2',3'-dideoxy-C(Ac) is N4-acetyl-2',3'-dideoxycytidine with a free 5'-hydroxyl and defined (2R,5S) sugar stereochemistry. CAS 119818-52-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2',3'-dideoxy-C(Ac) is classified as base-protected nucleosides (Formula C11H15N3O4; molecular weight 253.25).
2',3'-dideoxy-C(Ac) — Protected dideoxycytidine intermediate for research route development where the 5'-hydroxyl remains available for subsequent transformation.
For 2',3'-dideoxy-C(Ac), polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- N4-acetyl-2',3'-dideoxycytidine
Useful catalog search terms
- CAS 119818-52-9
Physicochemical data
| Base protection | N4-acetyl |
|---|---|
| Sugar substitution | 2',3'-dideoxy |
| Unprotected position | 5'-hydroxyl |
| Sugar stereochemistry | (2R,5S) |
| Systematic name | N-[1-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide |
| InChIKey | ZFDZWMCMWRPWDU-WCBMZHEXSA-N |
| InChI | InChI=1S/C11H15N3O4/c1-7(16)12-9-4-5-14(11(17)13-9)10-3-2-8(6-15)18-10/h4-5,8,10,15H,2-3,6H2,1H3,(H,12,13,16,17)/t8-,10+/m0/s1 |
| SMILES | CC(=O)NC1=NC(=O)N(C=C1)[C@H]2CC[C@H](O2)CO |
| Canonical SMILES | CC(=O)NC1=NC(=O)N(C=C1)[C@H]2CC[C@H](O2)CO |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
These points describe 2',3'-dideoxy-C(Ac) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2',3'-dideoxy-C(Ac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0002 and CAS 119818-52-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.