2'-F Nucleosides
2'-F-dA
Quick view. We supply 2'-F-dA as a 2'-fluoro deoxyadenosine/ribose analog for modified oligonucleotide and nucleotide synthesis. CAS 64183-27-3. Catalog target purity: Specification on request.
Product profile
2'-F-dA is classified as nucleoside or protected nucleoside intermediate (Formula C10H12FN5O3; molecular weight 269.23).
2'-F-dA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-F-dA, reported solubility: Acetonitrile (Slightly), Methanol (Slightly, Heated). Storage: Keep in dark place,Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-Deoxy-2'-fluoro-D-adenosine
- (2R,3R,4R,5R)-5-(6-Aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
- 2'-Fluoro-2'-deoxyadenosine
Useful catalog search terms
- CAS 64183-27-3
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| Melting point | 228 -231°C |
| Boiling point | 628.6±65.0 °C(Predicted) |
| Density | 2.01±0.1 g/cm3(Predicted) |
| pKa | 12.60±0.70(Predicted) |
| Form | Powder |
| Color | White to Off-white |
| InChI | InChI=1S/C10H12FN5O3/c11-5-7(18)4(1-17)19-10(5)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14) |
| InChIKey | ZGYYPTJWJBEXBC-UHFFFAOYSA-N |
| SMILES | Nc1ncnc2c1ncn2C1OC(CO)C(O)C1F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dA or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-F-dA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0180 and CAS 64183-27-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.