2'-F Nucleosides
2'-F-dC
Quick view. We supply 2'-F-dC as a 2'-fluoro cytidine analog for oligonucleotide monomer and nucleotide synthesis. CAS 10212-20-1. Catalog target purity: Specification on request.
Product profile
2'-F-dC is classified as nucleoside or protected nucleoside intermediate (Formula C9H12FN3O4; molecular weight 245.21).
2'-F-dC can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-F-dC, reported solubility: Soluble in DMSO, Methanol. Storage: Keep in dark place,Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-DEOXY-2'-FLUOROCYTIDINE
- 2'-FC
- 2'-FLUORO-2'-DEOXYCYTIDINE
- 2'-FLUORO-D-CYTIDINE
- 4-amino-1-[(2r,3r,4r,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
- 2'-DEOXY-2'-FLUOROCYTIDINE(2'-FLUORO-2'-DEOXYCYTIDINE, 2'-FC)
- 2'-Deoxy-2'-fluoro-D-cytidine
- 2'-Deoxy-2'-fluorocytidine Hydrate
Useful catalog search terms
- CAS 10212-20-1
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| Melting point | 167 °C |
| Boiling point | 500.1±60.0 °C(Predicted) |
| Density | 1.82±0.1 g/cm3(Predicted) |
| pKa | 12.84±0.70(Predicted) |
| Form | Powder |
| Color | White to Off-white |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O |
| InChI | InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s |
| InChIKey | NVZFZMCNALTPBY-XVFCMESISA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dC or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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Frequently asked questions
Can the package size for 2'-F-dC be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0182 and CAS 10212-20-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.