2'-F Nucleosides
2'-Deoxy-2'-fluoroguanosine
Quick view. 2'-Deoxy-2'-fluoroguanosine is a ribo-configured 2'-fluoro nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 78842-13-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-Deoxy-2'-fluoroguanosine is classified as 2'-fluoro nucleoside (Formula C10H12FN5O4; molecular weight 285.23).
A 2'-deoxy-2'-fluoroguanosine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-Deoxy-2'-fluoroguanosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-dG
- 2'-F-2'-dG
- Guanosine, 2'-deoxy-2'-fluoro-
Useful catalog search terms
- CAS 78842-13-4
- 2072145-29-8
Physicochemical data
| PubChem CID | 135415565 |
|---|---|
| InChIKey | UXUZARPLRQRNNX-DXTOWSMRSA-N |
| Modification | fluorine at the ribose 2'-position |
| InChI | InChI=1S/C10H12FN5O4/c11-4-6(18)3(1-17)20-9(4)16-2-13-5-7(16)14-10(12)15-8(5)19/h2-4,6,9,17-18H,1H2,(H3,12,14,15,19)/t3-,4-,6-,9-/m1/s1 |
| SMILES | N=c1nc(O)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3F)c2[nH]1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoroguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-2'-fluoroguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0183 and CAS 78842-13-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.