Other Phosphoramidites
2'-O-DMTr-N2-isobutyroyl-3'-O-methylguanosine 5'-CE phosphoramidite
Quick view. Guanosine phosphoramidite bearing 2'-O-DMTr, N2-isobutyroyl, and 3'-O-methyl protection with a 5'-cyanoethyl phosphoramidite group. CAS 2241581-19-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-DMTr-N2-isobutyroyl-3'-O-methylguanosine 5'-CE phosphoramidite is classified as other phosphoramidites (Formula C45H56N7O9P).
2'-O-DMTr-N2-isobutyroyl-3'-O-methylguanosine 5'-CE phosphoramidite can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For 2'-O-DMTr-N2-isobutyroyl-3'-O-methylguanosine 5'-CE phosphoramidite, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 2'-O-(4,4'-Dimethoxytrityl)-N2-isobutyroyl-3'-O-methylguanosine 5'-cyanoethyl N,N-diisopropylphosphoramidite
Useful catalog search terms
- 2241581-19-9
Physicochemical data
| Nucleoside scaffold | Guanosine |
|---|---|
| Protection pattern | 2'-O-DMTr; N2-isobutyroyl; 3'-O-methyl |
| Phosphoramidite position | 5' |
| Covalent InChIKey | JQINEXZOVKZNFS-MLLDKZSOSA-N |
| Covalent InChI | InChI=1S/C45H56N7O9P/c1-28(2)41(53)49-44-48-40-37(42(54)50-44)47-27-51(40)43-39(38(57-9)36(60-43)26-59-62(58-25-13-24-46)52(29(3)4)30(5)6)61-45(31-14-11-10-12-15-31,32-16-20-34(55-7)21-17-32)33-18-22-35(56-8)23-19-33/h10-12,14-23,27-30,36,38-39,43H,13,25-26H2,1-9H3,(H2,48,49,50,53,54)/t36-,38-,39-,43-,62?/m1/s1 |
| Covalent SMILES | COc1ccc(C(O[C@@H]2[C@H](OC)[C@@H](COP(OCCC#N)N(C(C)C)C(C)C)O[C@H]2n2cnc3c(=O)[nH]c(NC(=O)C(C)C)nc32)(c2ccccc2)c2ccc(OC)cc2)cc1 |
| Canonical covalent SMILES | COc1ccc(C(O[C@@H]2[C@H](OC)[C@@H](COP(OCCC#N)N(C(C)C)C(C)C)O[C@H]2n2cnc3c(=O)[nH]c(NC(=O)C(C)C)nc32)(c2ccccc2)c2ccc(OC)cc2)cc1 |
| Calculated molecular weight | 869.96 g/mol |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe 2'-O-DMTr-N2-isobutyroyl-3'-O-methylguanosine 5'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-DMTr-N2-isobutyroyl-3'-O-methylguanosine 5'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-OP-0100 and CAS 2241581-19-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.