2'-O-NMA Phosphoramidites
N4-Benzoyl-5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]cytidine-3'-CE phosphoramidite
Quick view. A protected 5-methylcytidine building block bearing N4-benzoyl and 5'-O-DMTr groups, a 2'-O-[2-(methylamino)-2-oxoethyl] substituent, and a 3'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 1025783-18-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of N4-Benzoyl-5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]cytidine-3'-CE phosphoramidite](/structures/30eb99844ae29f5e.svg)
Product profile
N4-Benzoyl-5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]cytidine-3'-CE phosphoramidite is classified as 2'-o-nma phosphoramidites (Formula C50H59N6O10P; molecular weight 935.03).
N4-Benzoyl-5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]cytidine-3'-CE phosphoramidite — Identity-defined 2'-O-NMA-5-Me-C(Bz) phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For N4-Benzoyl-5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]cytidine-3'-CE phosphoramidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2'-O-NMA-5-Me-C(Bz) phosphoramidite
- 5'-O-DMT-2'-O-NMA-5-Me-C(Bz)-3'-CE phosphoramidite
- N4-Bz-5'-O-DMTr-5-methyl-2'-O-(N-methylaminocarbonylmethyl)-cytidine 3'-CE phosphoramidite
Useful catalog search terms
- CAS 1025783-18-9
Physicochemical data
| InChIKey | OABRWFIIVWCDDM-WBHVIXSUSA-N |
|---|---|
| Nucleoside | 5-Methylcytidine |
| Base protection | N4-Benzoyl |
| 5' protection | DMTr |
| 2'-Modification | O-[2-(methylamino)-2-oxoethyl] (NMA) |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| PubChem CID | 177788710 |
| InChI | InChI=1S/C50H59N6O10P/c1-33(2)56(34(3)4)67(64-29-15-28-51)66-44-42(31-63-50(37-18-13-10-14-19-37,38-20-24-40(60-7)25-21-38)39-22-26-41(61-8)27-23-39)65-48(45(44)62-32-43(57)52-6)55-30-35(5)46(54-49(55)59)53-47(58)36-16-11-9-12-17-36/h9-14,16-27,30,33-34,42,44-45,48H,15,29,31-32H2,1-8H3,(H,52,57)(H,53,54,58,59)/t42-,44-,45-,48-,67?/m1/s1 |
| SMILES | CNC(=O)CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)O[C@H]1n1cc(C)c(NC(=O)c2ccccc2)nc1=O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe N4-Benzoyl-5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]cytidine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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2'-O-NMA Phosphoramidites · CAS: 1025783-20-3
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2'-O-NMA Phosphoramidites · CAS: 1025783-22-5
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2'-O-NMA Phosphoramidites · CAS: 1025783-16-7
Frequently asked questions
Can the package size for N4-Benzoyl-5'-O-DMTr-5-methyl-2'-O-[2-(methylamino)-2-oxoethyl]cytidine-3'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2ONP-0003 and CAS 1025783-18-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-NMA Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.