2'-O-NMA Phosphoramidites
N2-Isobutyryl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]guanosine-3'-CE phosphoramidite
Quick view. A protected guanosine building block bearing N2-isobutyryl and 5'-O-DMTr groups, a 2'-O-[2-(methylamino)-2-oxoethyl] substituent, and a 3'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 1025783-22-5. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of N2-Isobutyryl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]guanosine-3'-CE phosphoramidite](/structures/03c7021222dd45a4.svg)
Product profile
N2-Isobutyryl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]guanosine-3'-CE phosphoramidite is classified as 2'-o-nma phosphoramidites (Formula C47H59N8O10P; molecular weight 927.01).
N2-Isobutyryl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]guanosine-3'-CE phosphoramidite — Identity-defined 2'-O-NMA-G(iBu) phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For N2-Isobutyryl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]guanosine-3'-CE phosphoramidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2'-O-NMA-G(iBu) phosphoramidite
- 5'-O-DMT-2'-O-NMA-G(iBu)-3'-CE phosphoramidite
- N2-iBu-5'-O-DMTr-2'-O-(N-methylaminocarbonylmethyl)-guanosine 3'-CE phosphoramidite
Useful catalog search terms
- CAS 1025783-22-5
Physicochemical data
| InChIKey | BNLNDNDXCOPBTF-NCJSJSGWSA-N |
|---|---|
| Nucleoside | Guanosine |
| Base protection | N2-Isobutyryl |
| 5' protection | DMTr |
| 2'-Modification | O-[2-(methylamino)-2-oxoethyl] (NMA) |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| PubChem CID | 168441196 |
| InChI | InChI=1S/C47H59N8O10P/c1-29(2)43(57)52-46-51-42-39(44(58)53-46)50-28-54(42)45-41(61-27-38(56)49-7)40(65-66(63-25-13-24-48)55(30(3)4)31(5)6)37(64-45)26-62-47(32-14-11-10-12-15-32,33-16-20-35(59-8)21-17-33)34-18-22-36(60-9)23-19-34/h10-12,14-23,28-31,37,40-41,45H,13,25-27H2,1-9H3,(H,49,56)(H2,51,52,53,57,58)/t37-,40-,41-,45-,66?/m1/s1 |
| SMILES | CNC(=O)CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)O[C@H]1n1cnc2c(=O)[nH]c(NC(=O)C(C)C)nc21 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe N2-Isobutyryl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]guanosine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N2-Isobutyryl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]guanosine-3'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2ONP-0002 and CAS 1025783-22-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-NMA Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.