2'-O-NMA Phosphoramidites
N6-Benzoyl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]adenosine-3'-CE phosphoramidite
Quick view. A protected adenosine building block bearing N6-benzoyl and 5'-O-DMTr groups, a 2'-O-[2-(methylamino)-2-oxoethyl] substituent, and a 3'-cyanoethyl N,N-diisopropylphosphoramidite functionality. CAS 1025783-20-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
![Chemical structure of N6-Benzoyl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]adenosine-3'-CE phosphoramidite](/structures/7a5c81a1cc005f42.svg)
Product profile
N6-Benzoyl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]adenosine-3'-CE phosphoramidite is classified as 2'-o-nma phosphoramidites (Formula C50H57N8O9P; molecular weight 945.03).
N6-Benzoyl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]adenosine-3'-CE phosphoramidite — Identity-defined 2'-O-NMA-A(Bz) phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For N6-Benzoyl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]adenosine-3'-CE phosphoramidite, functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
Names and search terms
Confirmed or normalized name variants
- 2'-O-NMA-A(Bz) phosphoramidite
- 5'-O-DMT-2'-O-NMA-A(Bz)-3'-CE phosphoramidite
- N6-Bz-5'-O-DMTr-2'-O-(N-methylaminocarbonylmethyl)-adenosine 3'-CE phosphoramidite
Useful catalog search terms
- CAS 1025783-20-3
Physicochemical data
| InChIKey | GEYNOJIHDLPUEX-GNUXOQNYSA-N |
|---|---|
| Nucleoside | Adenosine |
| Base protection | N6-Benzoyl |
| 5' protection | DMTr |
| 2'-Modification | O-[2-(methylamino)-2-oxoethyl] (NMA) |
| 3'-Coupling group | 2-Cyanoethyl N,N-diisopropylphosphoramidite |
| PubChem CID | 168440831 |
| InChI | InChI=1S/C50H57N8O9P/c1-33(2)58(34(3)4)68(65-28-14-27-51)67-44-41(29-64-50(36-17-12-9-13-18-36,37-19-23-39(61-6)24-20-37)38-21-25-40(62-7)26-22-38)66-49(45(44)63-30-42(59)52-5)57-32-55-43-46(53-31-54-47(43)57)56-48(60)35-15-10-8-11-16-35/h8-13,15-26,31-34,41,44-45,49H,14,28-30H2,1-7H3,(H,52,59)(H,53,54,56,60)/t41-,44-,45-,49-,68?/m1/s1 |
| SMILES | CNC(=O)CO[C@@H]1[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H](COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)O[C@H]1n1cnc2c(NC(=O)c3ccccc3)ncnc21 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Reactive handles make the product adaptable across dye-labeling, surface-coupling and ligand-conjugation workflows.
Method limitations
- Functional handles may require orthogonal protection, pH control and rapid purification to avoid hydrolysis, oxidation or cross-reaction.
These points describe N6-Benzoyl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]adenosine-3'-CE phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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2'-O-NMA Phosphoramidites · CAS: 1025783-18-9
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2'-O-NMA Phosphoramidites · CAS: 1025783-16-7
Frequently asked questions
Can the package size for N6-Benzoyl-5'-O-DMTr-2'-O-[2-(methylamino)-2-oxoethyl]adenosine-3'-CE phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2ONP-0001 and CAS 1025783-20-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-NMA Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.