DMTr-protected Nucleosides
3'-O-DMTr-2'-O-Me-rU
Quick view. 2'-O-methyluridine bearing a 3'-O-DMTr group and a free 5'-hydroxyl. A public CAS number is not assigned for this exact form. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
3'-O-DMTr-2'-O-Me-rU is classified as dmtr-protected nucleosides.
3'-O-DMTr-2'-O-Me-rU supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 3'-O-DMTr-2'-O-Me-rU, excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- 3'-O-DMTr-2'-O-methyluridine
- 3'-O-DMT-2'-O-Me-rU
Physicochemical data
| Nucleoside | Uridine |
|---|---|
| Sugar modification | 2'-O-methyl |
| Hydroxyl protection | 3'-O-DMTr |
| Hydroxyl state | 5' hydroxyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 3'-O-DMTr-2'-O-Me-rU or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3'-O-DMTr-2'-O-Me-rG(iBu)
DMTr-protected Nucleosides · CAS: N/A
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BX-PN-00265'-O-DMTr-2'-F-dC(Bz)
DMTr-protected Nucleosides · CAS: N/A
BX-PN-00275'-O-DMTr-2'-O-(2-aminoethyl)-5-Me-rU
DMTr-protected Nucleosides · CAS: 242147-79-1
BX-PN-00285'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac)
DMTr-protected Nucleosides · CAS: 863408-41-7
BX-PN-00295'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rC(Ac)
DMTr-protected Nucleosides · CAS: 863408-42-8
Frequently asked questions
Can the package size for 3'-O-DMTr-2'-O-Me-rU be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0019, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.