3'-O-Me Nucleosides
N7-Methyl-3'-O-methylguanosine
Quick view. A guanosine derivative methylated at N7 of the base and O-3' of the ribose, identified by CAS 2590868-43-0. CAS 2590868-43-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N7-Methyl-3'-O-methylguanosine is classified as 3'-o-me nucleosides (Formula C12H19N5O5; molecular weight 313.31).
N7-Methyl-3'-O-methylguanosine can be evaluated in terminally blocked nucleotide, cap-chemistry and analytical-reference workflows where 3′-O-methylation changes extension or end-group reactivity.
For N7-Methyl-3'-O-methylguanosine, the 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
Names and search terms
Confirmed or normalized name variants
- 7,3'-O-Dimethylguanosine
Useful catalog search terms
- CAS 2590868-43-0
- PubChem CID 136650374
Physicochemical data
| Base modification | N7-Methyl |
|---|---|
| Sugar modification | 3'-O-Methyl |
| Available hydroxyls | 2'-OH and 5'-OH |
| InChIKey | VLQOLNREUGFTMV-IOSLPCCCSA-N |
| PubChem CID | 136650374 |
| InChI | InChI=1S/C12H19N5O5/c1-16-4-17(9-6(16)10(20)15-12(13)14-9)11-7(19)8(21-2)5(3-18)22-11/h5,7-8,11,18-19H,3-4H2,1-2H3,(H3,13,14,15,20)/t5-,7-,8-,11-/m1/s1 |
| SMILES | CN1CN(C2=C1C(=O)NC(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 3′-O-methylation provides a defined blocked ribose terminus and is analytically distinguishable from the corresponding 2′-O-methyl isomer.
Method limitations
- The 3′-O-methyl group blocks normal 3′-hydroxyl extension; confirm that this behavior matches the intended enzyme or synthesis workflow.
These points describe N7-Methyl-3'-O-methylguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N7-Methyl-3'-O-methylguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-3OMN-0008 and CAS 2590868-43-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 3'-O-Me Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.