Cap Analogs
ARCA (m2(7,3'-O)GpppG)
Quick view. A 3'-O-methyl anti-reverse dinucleotide cap analog for co-transcriptional mRNA capping research. CAS 400806-46-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
ARCA (m2(7,3'-O)GpppG) is classified as cap analogs (Formula C22H31N10O18P3; molecular weight 816.46 g/mol).
ARCA (m2(7,3'-O)GpppG) — Cap dinucleotide for co-transcriptional mRNA capping in in-vitro-transcription research.
For ARCA (m2(7,3'-O)GpppG), capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
Names and search terms
Confirmed or normalized name variants
- Anti-Reverse Cap Analog
- m2(7,3'-O)GpppG
- 7-methyl(3'-O-methyl)GpppG
Useful catalog search terms
- CAS 400806-46-4
Physicochemical data
| Registered form | Free acid |
|---|---|
| Structural shorthand | m2(7,3'-O)GpppG |
| Cap modification | N7-methyl and 3'-O-methyl on the cap guanosine |
| Linkage | 5'-5' triphosphate bridge |
| PubChem CID | 137169098 |
| InChIKey | AIRSQUYUYJSIIM-XPWFQUROSA-N |
| InChI | InChI=1S/C22H31N10O18P3/c1-30-6-32(16-10(30)18(37)29-22(24)27-16)20-13(35)14(44-2)8(48-20)4-46-52(40,41)50-53(42,43)49-51(38,39)45-3-7-11(33)12(34)19(47-7)31-5-25-9-15(31)26-21(23)28-17(9)36/h5-8,11-14,19-20,33-35H,3-4H2,1-2H3,(H8-,23,24,26,27,28,29,36,37,38,39,40,41,42,43)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1 |
| SMILES | CN1C=[N+](C2=C1C(=O)NC(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=NC6=C5N=C(NC6=O)N)O)O)OC)O |
| Canonical SMILES | CN1C=[N+](C2=C1C(=O)NC(=N2)N)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=NC6=C5N=C(NC6=O)N)O)O)OC)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Cap analog selection can influence capping efficiency, orientation and downstream translation-related performance.
Method limitations
- Capping outcome depends on polymerase system, cap-to-NTP ratio, transcript design and purification method.
These points describe ARCA (m2(7,3'-O)GpppG) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for ARCA (m2(7,3'-O)GpppG) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CA-0001 and CAS 400806-46-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.