Cyclic Dinucleotides
c-di-AMP diammonium salt
Quick view. We supply c-di-AMP diammonium salt as a dry cyclic-dinucleotide material for second-messenger research. CAS 1465774-27-9. Catalog target purity: ≥98%.
Product profile
c-di-AMP diammonium salt is classified as cyclic dinucleotide second messenger or analog (Formula C20H30N12O12P2; molecular weight 692.47).
c-di-AMP diammonium salt can support enzyme-substrate, in-vitro transcription, polymerase-screening or analytical-reference studies as appropriate to its phosphate state.
For c-di-AMP diammonium salt, reported solubility: Water: soluble. Storage: Store at -20°C.
Names and search terms
Confirmed or normalized name variants
- Cyclic di-AMP diammonium
- c-di-adenosine monophosphate diammonium
- 2'2'-cGAMP
- 2’2’-cGAMP (sodium salt)
Useful catalog search terms
- CAS 1465774-27-9
- Cyclic Dinucleotides
- Cyclic dinucleotide second messenger or analog
- cyclic dinucleotide topology
Physicochemical data
| Key chemistry motifs | cyclic dinucleotide topology |
|---|---|
| Purity basis | Research-grade target; the lot-specific CoA reports the release result and analytical method. |
| Counterion | Diammonium |
| Supply form | Dry salt |
| Boiling point | 1159.9±75.0 °C(Predicted) |
| Density | 2.61±0.1 g/cm3(Predicted) |
| pKa | 0.88±0.70(Predicted) |
| Form | A crystalline solid |
| SMILES | C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)OP(=O)(OC[C@@H]5[C@H]([C@H]([C@@H](O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O |
| Identity note | The catalog item is the diammonium salt; confirm counterion, hydration and endotoxin requirements separately. |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical qualification includes identity, salt/counterion, assay basis, water content and enzyme compatibility.
- Related uses include LC-MS/HPLC method development and comparison with native or modified nucleotide controls.
Product-specific evaluation notes
Potential advantages
- Defined linkage isomers and counterion forms allow controlled comparisons across cyclic-dinucleotide assay conditions.
Method limitations
- Activity can depend on linkage stereochemistry, receptor variant, cell entry, salt form and assay format; molar calculations should use the exact supplied form.
These points describe c-di-AMP diammonium salt or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for c-di-AMP diammonium salt be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-CDN-0011 and CAS 1465774-27-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Cyclic Dinucleotides product family and its named chemistry.
- Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
- Cyclic G(2',5')pA(3',5')p is the metazoan second messenger produced by cGAS
- STING is a direct innate immune sensor of cyclic di-GMP
- Cyclic di-AMP secreted by Listeria monocytogenes activates a host type I interferon response