Other Phosphoramidites
DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite
Quick view. A protected cytidine phosphoramidite with geminal 2',2'-difluoro substitution, 5-O-DMTr protection and an N4-benzoyl-protected cytosine base. CAS 142808-44-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite is classified as protected geminal-difluoro cytidine phosphoramidite (Formula C46H50F2N5O8P; molecular weight 869.89).
DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-2',2'-difluoro-dC(Bz)-3'-CED-phosphoramidite
- Gemcitabine 3'-CE phosphoramidite
Useful catalog search terms
- 142808-44-4
Physicochemical data
| Nucleoside modification | 2',2'-Difluoro-2'-deoxycytidine |
|---|---|
| Protecting groups | 5-O-DMTr; N4-benzoyl |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for DMTr-2',2'-diFluoro-dC(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-OP-0014 and CAS 142808-44-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.