Other Phosphoramidites
DMTr-2',2'-diFluoro-dG(iBu)-3'-CE-Phosphoramidite
Quick view. A protected guanosine phosphoramidite with geminal 2',2'-difluoro substitution, 5-O-DMTr protection and an N2-isobutyryl-protected guanine base. A public CAS number is not assigned for this exact form. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2',2'-diFluoro-dG(iBu)-3'-CE-Phosphoramidite is classified as protected geminal-difluoro guanosine phosphoramidite (Formula C44H52F2N7O8P; molecular weight 875.91).
DMTr-2',2'-diFluoro-dG(iBu)-3'-CE-Phosphoramidite is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For DMTr-2',2'-diFluoro-dG(iBu)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 5'-O-DMTr-N2-isobutyryl-2',2'-difluoro-dG-3'-CED-phosphoramidite
- Synthgene PA263
Useful catalog search terms
- PA263
Physicochemical data
| Nucleoside modification | 2',2'-Difluoro-2'-deoxyguanosine |
|---|---|
| Protecting groups | 5-O-DMTr; N2-isobutyryl |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2',2'-diFluoro-dG(iBu)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
3-Cyanovinylcarbazole Phosphoramidite
Other Phosphoramidites · CAS: 1157899-72-3
BX-OP-00025'-O-DMTr-2'-O-MOE-5-Me-rC(Bz) Bis(phosphoramidite)
Other Phosphoramidites · CAS: N/A
BX-OP-00035'-O-DMTr-2'-O-MOE-rG(iBu) Bis(phosphoramidite)
Other Phosphoramidites · CAS: N/A
BX-OP-00045'-O-DMTr-2'-O-MOE-rT Bis(phosphoramidite)
Other Phosphoramidites · CAS: N/A
BX-OP-00065'-DMT Amino-Modifier C6 Phosphoramidite
Other Phosphoramidites · CAS: 116919-15-4
BX-OP-0007Bis(5'-O-DMTr-2'-O-MOE-5-Me-rC(Bz)-3'-oxy)-diisopropylphosphoramidite
Other Phosphoramidites · CAS: N/A
Frequently asked questions
Can the package size for DMTr-2',2'-diFluoro-dG(iBu)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-OP-0015, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Other Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.