2'-Fluoro Phosphoramidites
DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite is an N6-benzoyl-protected 2'-fluoro-2'-deoxyadenosine building block for research-use oligonucleotide synthesis. CAS 136834-22-5. Catalog target purity: 99%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite is classified as protected 2'-fluoro-2'-deoxyadenosine phosphoramidite (Formula C47H51FN7O7P; molecular weight 875.90).
DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite — N6-benzoyl-protected 2'-fluoro-2'-deoxyadenosine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-dA(Bz) Phosphoramidite
- DMT-2'-F-dA(Bz)-CE Phosphoramidite
- N6-Benzoyl-5'-O-DMTr-2'-fluoro-2'-deoxyadenosine-3'-CE Phosphoramidite
Useful catalog search terms
- 136834-22-5
- PubChem 12042896
- C47H51FN7O7P
- Thermo Fisher 27-1601-00
Physicochemical data
| Base protection | N6-benzoyl |
|---|---|
| Sugar modification | 2'-fluoro-2'-deoxy |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | VCCMVPDSLHFCBB-MSIRFHFKSA-N |
| InChI | InChI=1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-39(61-46(40(42)48)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1F)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC |
| PubChem CID | 12042896 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-2FP-0003DMTr-2'-F-dC(Bz)-3'-(D)-DPSE-Phosphoramidite
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BX-2FP-0004DMTr-2'-F-dC(Bz)-3'-(L)-DPSE-Phosphoramidite
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BX-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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BX-2FP-0006DMTr-2'-F-dG(dmf)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-F-dA(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0026 and CAS 136834-22-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.