2'-Fluoro Phosphoramidites
DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite is an N4-acetyl-protected 2'-fluoro-2'-deoxycytidine building block for research-use oligonucleotide synthesis. CAS 159414-99-0. Catalog target purity: ≥98.0%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite is classified as protected 2'-fluoro-2'-deoxycytidine phosphoramidite (Formula C41H49FN5O8P; molecular weight 789.80).
DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite — N4-acetyl-protected 2'-fluoro-2'-deoxycytidine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-dC(Ac) Phosphoramidite
- DMT-2'-F-dC(Ac)-CE Phosphoramidite
- N4-Acetyl-5'-O-DMTr-2'-fluoro-2'-deoxycytidine-3'-CE Phosphoramidite
Useful catalog search terms
- 159414-99-0
- PubChem 67090252
- C41H49FN5O8P
Physicochemical data
| Base protection | N4-acetyl |
|---|---|
| Sugar modification | 2'-fluoro-2'-deoxy |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | CNFKJHKDSRXNFL-UTXREMQHSA-N |
| InChI | InChI=1S/C41H49FN5O8P/c1-27(2)47(28(3)4)56(53-25-11-23-43)55-38-35(54-39(37(38)42)46-24-22-36(44-29(5)48)45-40(46)49)26-52-41(30-12-9-8-10-13-30,31-14-18-33(50-6)19-15-31)32-16-20-34(51-7)21-17-32/h8-10,12-22,24,27-28,35,37-39H,11,25-26H2,1-7H3,(H,44,45,48,49)/t35-,37-,38-,39-,56?/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(NC(C)=O)nc3=O)[C@H](F)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-2FP-0003DMTr-2'-F-dC(Bz)-3'-(D)-DPSE-Phosphoramidite
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BX-2FP-0004DMTr-2'-F-dC(Bz)-3'-(L)-DPSE-Phosphoramidite
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BX-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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BX-2FP-0006DMTr-2'-F-dG(dmf)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-F-dC(Ac)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0025 and CAS 159414-99-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.