2'-Fluoro Phosphoramidites
DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite
Quick view. DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite is an N4-benzoyl-protected 2'-fluoro-2'-deoxycytidine building block for research-use oligonucleotide synthesis. CAS 161442-19-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite is classified as protected 2'-fluoro-2'-deoxycytidine phosphoramidite (Formula C46H51FN5O8P; molecular weight 851.90).
DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite — N4-benzoyl-protected 2'-fluoro-2'-deoxycytidine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-dC(Bz) Phosphoramidite
- DMT-2'-F-dC(Bz)-CE Phosphoramidite
- N4-Benzoyl-5'-O-DMTr-2'-fluoro-2'-deoxycytidine-3'-CE Phosphoramidite
Useful catalog search terms
- 161442-19-9
- PubChem 10328204
- C46H51FN5O8P
Physicochemical data
| Base protection | N4-benzoyl |
|---|---|
| Sugar modification | 2'-fluoro-2'-deoxy |
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | CKKJPMGSTGVCJJ-GNUWXFRUSA-N |
| InChI | InChI=1S/C46H51FN5O8P/c1-31(2)52(32(3)4)61(58-29-13-27-48)60-42-39(59-44(41(42)47)51-28-26-40(50-45(51)54)49-43(53)33-14-9-7-10-15-33)30-57-46(34-16-11-8-12-17-34,35-18-22-37(55-5)23-19-35)36-20-24-38(56-6)25-21-36/h7-12,14-26,28,31-32,39,41-42,44H,13,29-30H2,1-6H3,(H,49,50,53,54)/t39-,41-,42-,44-,61?/m1/s1 |
| SMILES | CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1F)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC |
| PubChem CID | 10328204 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2FP-0003DMTr-2'-F-dC(Bz)-3'-(D)-DPSE-Phosphoramidite
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BX-2FP-0004DMTr-2'-F-dC(Bz)-3'-(L)-DPSE-Phosphoramidite
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BX-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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BX-2FP-0006DMTr-2'-F-dG(dmf)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-F-dC(Bz)-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0028 and CAS 161442-19-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.