2'-Fluoro Phosphoramidites
DMTr-2'-F-dU-3'-CE-Phosphoramidite
Quick view. DMTr-2'-F-dU-3'-CE-Phosphoramidite is a 2'-fluoro-2'-deoxyuridine building block for research-use oligonucleotide synthesis. CAS 146954-75-8. Catalog target purity: ≥98.0%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
DMTr-2'-F-dU-3'-CE-Phosphoramidite is classified as 2'-fluoro-2'-deoxyuridine phosphoramidite (Formula C39H46FN4O8P; molecular weight 748.80).
DMTr-2'-F-dU-3'-CE-Phosphoramidite — 2'-fluoro-2'-deoxyuridine phosphoramidite building block for research-use oligonucleotide synthesis.
For DMTr-2'-F-dU-3'-CE-Phosphoramidite, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-F-dU Phosphoramidite
- DMT-2'-F-dU-CE Phosphoramidite
- 5'-O-DMTr-2'-fluoro-2'-deoxyuridine-3'-CE Phosphoramidite
Useful catalog search terms
- 146954-75-8
- PubChem 9810693
- C39H46FN4O8P
Physicochemical data
| Sugar modification | 2'-fluoro-2'-deoxy |
|---|---|
| Synthesis format | 5'-DMTr and 3'-2-cyanoethyl N,N-diisopropyl phosphoramidite |
| InChIKey | HQHQPAYRJJMYQX-DJTPZYMWSA-N |
| InChI | InChI=1S/C39H46FN4O8P/c1-26(2)44(27(3)4)53(50-24-10-22-41)52-36-33(51-37(35(36)40)43-23-21-34(45)42-38(43)46)25-49-39(28-11-8-7-9-12-28,29-13-17-31(47-5)18-14-29)30-15-19-32(48-6)20-16-30/h7-9,11-21,23,26-27,33,35-37H,10,24-25H2,1-6H3,(H,42,45,46)/t33-,35-,36-,37-,53?/m1/s1 |
| SMILES | COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(O)nc3=O)[C@H](F)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe DMTr-2'-F-dU-3'-CE-Phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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BX-2FP-0005DMTr-2'-F-dG(dmf)-3'-(L)-PSM-Phosphoramidite
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BX-2FP-0006DMTr-2'-F-dG(dmf)-3'-CE-Phosphoramidite
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Frequently asked questions
Can the package size for DMTr-2'-F-dU-3'-CE-Phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FP-0024 and CAS 146954-75-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-Fluoro Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.