2'-F Nucleosides
2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine
Quick view. A 2'-deoxy-2'-fluorouridine derivative protected as the 3',5'-bis-O-TBDMS ether, CAS 139878-36-7. CAS 139878-36-7. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine is classified as 2'-f nucleosides (Formula C21H39FN2O5Si2; molecular weight 474.71).
2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- Uridine, 2'-deoxy-3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-
Useful catalog search terms
- CAS 139878-36-7
- MCE HY-154236
Physicochemical data
| SMILES | CC(C)(C)[Si](C)(C)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=O)NC2=O)F)O[Si](C)(C)C(C)(C)C |
|---|---|
| Sugar substitution | 2'-Deoxy-2'-fluoro |
| Hydroxyl protection | 3'-O- and 5'-O-TBDMS |
| Nucleobase | Uracil (pyrimidine) |
| Product form | Protected nucleoside (not phosphoramidite) |
| PubChem CID | 15719974 |
| InChIKey | NLTNXZUKPKJZQK-VDHUWJSZSA-N |
| InChI | InChI=1S/C21H39FN2O5Si2/c1-20(2,3)30(7,8)27-13-14-17(29-31(9,10)21(4,5)6)16(22)18(28-14)24-12-11-15(25)23-19(24)26/h11-12,14,16-18H,13H2,1-10H3,(H,23,25,26)/t14-,16-,17-,18-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-2'-fluoro-3',5'-bis-O-TBDMS-uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0040 and CAS 139878-36-7, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.