2'-F Nucleosides
2'-Deoxy-2'-fluoroisocytidine
Quick view. A beta-D 2'-deoxy-2'-fluoro isocytidine building block for structure-specific modified-oligonucleotide synthesis research. CAS 1668560-65-3. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-Deoxy-2'-fluoroisocytidine is classified as 2'-f nucleosides (Formula C9H12FN3O4; molecular weight 245.21).
2'-Deoxy-2'-fluoroisocytidine — 2'-Fluoro isocytidine building block for structure-specific modified-oligonucleotide synthesis research.
For 2'-Deoxy-2'-fluoroisocytidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2-Amino-1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-4(1H)-pyrimidinone
Useful catalog search terms
- CAS 1668560-65-3
- 2-fluoro isocytidine
Physicochemical data
| Nucleobase | Isocytosine (pyrimidine) |
|---|---|
| Sugar modification | 2'-deoxy-2'-fluoro beta-D-ribofuranosyl |
| PubChem CID | 122395473 |
| InChI | InChI=1S/C9H12FN3O4/c10-6-7(16)4(3-14)17-8(6)13-2-1-5(15)12-9(13)11/h1-2,4,6-8,14,16H,3H2,(H2,11,12,15)/t4-,6-,7-,8-/m1/s1 |
| InChIKey | BCZCJFDTXSJBPW-XVFCMESISA-N |
| SMILES | C1=CN(C(=NC1=O)N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Primary literature reports preparation of the corresponding phosphoramidite and its use in solid-phase oligonucleotide synthesis; reported reaction conditions should not be treated as a BX batch guarantee.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-Deoxy-2'-fluoroisocytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-Deoxy-2'-fluoroisocytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0053 and CAS 1668560-65-3, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-relevant literature
The publications below discuss named chemistry or a structural feature represented by this product. They provide scientific context only and are not a BX Lab lot specification or product-performance claim.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.