Base-protected Nucleosides
2'-F-dC(Bz)
Quick view. We supply 2'-F-dC(Bz) as a protected 2'-fluoro nucleoside precursor for modified oligonucleotide and nucleotide synthesis. CAS 146954-76-9. Catalog target purity: Specification on request.
Product profile
2'-F-dC(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C16H16FN3O5; molecular weight 349.31).
2'-F-dC(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-F-dC(Bz), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N4-Bz-2'-F-dC
- N-Benzoyl-2'-deoxy-2'-fluorocytidine
- N4-Benzoyl-2'-deoxy-2'-fluorocytidine
- Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-
- N4-benzoyl-2'-deoxy-2'-fluoro-2'-deoxycytidine
Useful catalog search terms
- CAS 146954-76-9
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| Density | 1.56±0.1 g/cm3(Predicted) |
| pKa | 8.52±0.20(Predicted) |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 2'-F-dC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-F-dC(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0098 and CAS 146954-76-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.