Base-protected Nucleosides
2'-O-Me-rG(iBu)
Quick view. We supply 2'-O-Me-rG(iBu) as a protected 2'-O-methyl nucleoside precursor for modified RNA and oligonucleotide monomer synthesis. CAS 63264-29-9. Catalog target purity: Specification on request.
Product profile
2'-O-Me-rG(iBu) is classified as nucleoside or protected nucleoside intermediate (Formula C15H21N5O6; molecular weight 367.36).
2'-O-Me-rG(iBu) — N2-Isobutyryl-2'-O-methylguanosine is a useful intermediate in the synthesis and probes of novel nucleic acids.
For 2'-O-Me-rG(iBu), form: Solid.
Names and search terms
Confirmed or normalized name variants
- iBu-2'-OMe-G
- N2-ibu-2'-OMe-G
- N2-iBu-2'-O-Me-Gr
- 2'-O-Methyl-N2-isobutyroylguanosine
- N2-Isobutyryl-2'-O-Methyl-guanosine
- Guanosine, 2'-O-Methyl-N-(2-Methyl-1-oxopropyl)-
Useful catalog search terms
- CAS 63264-29-9
- Nucleoside or protected nucleoside intermediate
- 2'-O-methyl modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-methyl modification |
|---|---|
| Density | 1.68±0.1 g/cm3(Predicted) |
| pKa | 9.16±0.20(Predicted) |
| Form | Solid |
| Color | White to off-white |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-Me-rG(iBu) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2',3'-dideoxy-C(Ac)
Base-protected Nucleosides · CAS: 119818-52-9
BX-PN-00032',3'-dideoxy-C(Bz)
Base-protected Nucleosides · CAS: 120885-60-1
BX-PN-00052'-F-dG(DMF)
Base-protected Nucleosides · CAS: N/A
BX-PN-00062'-O-4'-C-Locked-5-Me-rC(Bz)
Base-protected Nucleosides · CAS: 206055-81-4
BX-PN-00072'-O-4'-C-Locked-rC(Bz)
Base-protected Nucleosides · CAS: 221229-74-9
BX-PN-00092'-O-4'-C-Locked-rG(iBu)
Base-protected Nucleosides · CAS: 206055-68-7
Frequently asked questions
Can the package size for 2'-O-Me-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0099 and CAS 63264-29-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.