Base-protected Nucleosides
2'-O-Me-rG(iBu)
Quick view. N2-Isobutyryl-2'-O-methylguanosine with free 3'- and 5'-hydroxyl groups. CAS 63264-29-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-Me-rG(iBu) is classified as base-protected nucleosides (Formula C15H21N5O6; molecular weight 367.36).
2'-O-Me-rG(iBu) supports modified RNA/antisense designs where methylated ribose positions are used to improve stability or reduce unwanted immune stimulation.
For 2'-O-Me-rG(iBu), excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
Names and search terms
Confirmed or normalized name variants
- N2-Isobutyryl-2'-O-methylguanosine
- N2-iBu-2'-O-Me-rG
Useful catalog search terms
- CAS 63264-29-9
Physicochemical data
| PubChem CID | 135536008 |
|---|---|
| InChIKey | RPULCYXEYODQOG-AKAIJSEGSA-N |
| Nucleoside | Guanosine |
| Base protection | N2-isobutyryl |
| Sugar modification | 2'-O-methyl |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-methyl groups are widely used to increase nuclease resistance and modulate hybridization behavior.
Method limitations
- Excessive or poorly positioned substitution can reduce desired enzyme interactions or activity in some assay formats.
These points describe 2'-O-Me-rG(iBu) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-Me-rG(iBu) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0099 and CAS 63264-29-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.