Base-protected Nucleosides
2'-O-MOE-5-Me-rC(Bz)
Quick view. N4-Benzoyl-5-methylcytidine bearing a 2'-O-(2-methoxyethyl) group and free 3'- and 5'-hydroxyl groups. CAS 340162-93-8. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-MOE-5-Me-rC(Bz) is classified as base-protected nucleosides (Formula C20H25N3O7; molecular weight 419.43).
2'-O-MOE-5-Me-rC(Bz) is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 2'-O-MOE-5-Me-rC(Bz), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N4-Benzoyl-2'-O-(2-methoxyethyl)-5-methylcytidine
- 2'-O-MOE-N4-Bz-5-Me-rC
- N4-Bz-2'-O-MOE-5-Me-rC
Useful catalog search terms
- CAS 340162-93-8
Physicochemical data
| InChIKey | LGGHYGUGIGYDFX-YKTARERQSA-N |
|---|---|
| Nucleoside | 5-Methylcytidine |
| Base protection | N4-benzoyl |
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
| InChI | InChI=1S/C20H25N3O7/c1-12-10-23(19-16(29-9-8-28-2)15(25)14(11-24)30-19)20(27)22-17(12)21-18(26)13-6-4-3-5-7-13/h3-7,10,14-16,19,24-25H,8-9,11H2,1-2H3,(H,21,22,26,27)/t14-,15-,16-,19-/m1/s1 |
| SMILES | CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OCCOC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-5-Me-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-5-Me-rC(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0080 and CAS 340162-93-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.