Base-protected Nucleosides
2'-O-MOE-5-Me-rC(Bz)
Quick view. We supply 2'-O-MOE-5-Me-rC(Bz) as a base- or sugar-protected nucleoside intermediate for nucleoside, nucleotide and oligonucleotide building-block synthesis. CAS 340162-93-8. Catalog target purity: Specification on request.
Product profile
2'-O-MOE-5-Me-rC(Bz) is classified as nucleoside or protected nucleoside intermediate (Formula C20H25N3O7; molecular weight 419.43).
2'-O-MOE-5-Me-rC(Bz) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For 2'-O-MOE-5-Me-rC(Bz), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N4-Bz-2'-O-MOE-5-Me-Cr
- 2’-MOE-N6-Bz-5-Methycytidine
- N4-Benzoyl-2'-O-(2-ethoxyethyl)-5-methylcytidine
- N4-Benzoyl-2'-O-(2-methoxyethyl)-5-methylcytidine
- Cytidine, N-benzoyl-2'-O-(2-methoxyethyl)-5-methyl-
- N-Benzoyl-2'-O-(2-methoxyethyl)-5-methylcytidine
Useful catalog search terms
- CAS 340162-93-8
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- Base-protected Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Density | 1.41±0.1 g/cm3(Predicted) |
| pKa | 8.61±0.40(Predicted) |
| InChI | InChI=1S/C20H25N3O7/c1-12-10-23(19-16(29-9-8-28-2)15(25)14(11-24)30-19)20(27)22-17(12)21-18(26)13-6-4-3-5-7-13/h3-7,10,14-16,19,24-25H,8-9,11H2,1-2H3,(H,21,22,26,27)/t14-,15-,16-,19-/m1/s |
| InChIKey | LGGHYGUGIGYDFX-YKTARERQSA-N |
| SMILES | CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OCCOC |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-5-Me-rC(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-5-Me-rC(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0080 and CAS 340162-93-8, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry.