2'-O-MOE Nucleosides
2'-O-MOE-rA
Quick view. We supply 2'-O-MOE-rA as a methoxyethyl adenosine nucleoside for ASO monomer preparation and MOE SAR. CAS 168427-74-5. Catalog target purity: Specification on request.
Product profile
2'-O-MOE-rA is classified as nucleoside or protected nucleoside intermediate (Formula C13H19N5O5; molecular weight 325.32).
2'-O-MOE-rA — A adenosine derivative as building blocks for cross-linking oligonucleotides.
For 2'-O-MOE-rA, reported solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly). Storage: Keep in dark place,Sealed in dry,2-8°C.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-A
- 2'-O-MOE-Ar
- 2'-O-MOE-ADENOSINE
- 2'-O-Methoxyethyl-adenosine
- 2'-O-MOE-ADENOSINE USP/EP/BP
- 2'-O-(2-METHOXYETHYL)ADENOSINE
- Adenosine, 2'-O-(2-Methoxyethyl)-
Useful catalog search terms
- CAS 168427-74-5
- Nucleoside or protected nucleoside intermediate
- 2'-O-MOE modification
- 2'-O-MOE Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-O-MOE modification |
|---|---|
| Melting point | 54-59°C |
| Boiling point | 639.0±65.0 °C(Predicted) |
| Density | 1.70±0.1 g/cm3(Predicted) |
| pKa | 13.12±0.70(Predicted) |
| Form | Solid |
| Color | White |
| SMILES | OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](OCCOC)[C@@H]1O |
| InChI | InChI=1S/C13H19N5O5/c1-21-2-3-22-10-9(20)7(4-19)23-13(10)18-6-17-8-11(14)15-5-16-12(8)18/h5-7,9-10,13,19-20H,2-4H2,1H3,(H2,14,15,16)/t7-,9-,10-,13-/m1/s |
| InChIKey | PUDXUJRJLRLJIU-QYVSTXNMSA-N |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 2'-O-MOE-rA can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rA or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-rA be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0169 and CAS 168427-74-5, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry.