2'-O-MOE Nucleosides
2'-O-(2-Methoxyethyl)uridine
Quick view. 2'-O-(2-Methoxyethyl)uridine is a 2'-O-MOE-modified nucleoside building block for research-use modified-nucleoside and oligonucleotide chemistry. CAS 223777-15-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-(2-Methoxyethyl)uridine is classified as 2'-o-moe nucleoside (Formula C12H18N2O7; molecular weight 302.28).
2'-O-(2-Methoxyethyl)uridine — A 2'-O-(2-methoxyethyl)-modified uridine building block for research-use modified-nucleoside and oligonucleotide chemistry.
For 2'-O-(2-Methoxyethyl)uridine, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-rU
- 2'-O-MOE Uridine
- Uridine, 2'-O-(2-methoxyethyl)-
Useful catalog search terms
- CAS 223777-15-9
Physicochemical data
| PubChem CID | 10881175 |
|---|---|
| InChIKey | XTXNROBDOKPICP-QCNRFFRDSA-N |
| Modification | 2-methoxyethyl ether at the ribose 2'-oxygen |
| InChI | InChI=1S/C12H18N2O7/c1-19-4-5-20-10-9(17)7(6-15)21-11(10)14-3-2-8(16)13-12(14)18/h2-3,7,9-11,15,17H,4-6H2,1H3,(H,13,16,18)/t7-,9-,10-,11-/m1/s1 |
| SMILES | COCCO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-(2-Methoxyethyl)uridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
2'-O-(2-Methoxyethyl)inosine
2'-O-MOE Nucleosides · CAS: 545374-76-3
BX-MN-01672'-O-(2-Methoxyethyl)-5-methylcytidine
2'-O-MOE Nucleosides · CAS: 244105-55-3
BX-MN-01682'-O-(2-Methoxyethyl)guanosine
2'-O-MOE Nucleosides · CAS: 473278-54-5
BX-MN-01692'-O-(2-Methoxyethyl)adenosine
2'-O-MOE Nucleosides · CAS: 168427-74-5
BX-MN-01702'-O-(2-Methoxyethyl)cytidine
2'-O-MOE Nucleosides · CAS: 223777-16-0
BX-MN-01742'-O-(2-Methoxyethyl)-5-methyluridine
2'-O-MOE Nucleosides · CAS: 163759-49-7
Frequently asked questions
Can the package size for 2'-O-(2-Methoxyethyl)uridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-MN-0171 and CAS 223777-15-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-O-MOE Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.