Thio Phosphoramidites
N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite
Quick view. A protected adenosine building block bearing N6-benzoyl, 5'-O-DMTr, and 2'-O-methoxyethyl groups with a 3'-S-(2-benzoylmercaptoethyl) pyrrolidino thiophosphoramidite functionality. CAS 2360826-72-6. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite is classified as thio phosphoramidites (Formula C54H57N6O9PS2; molecular weight 1029.18).
N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite — Identity-defined 2'-O-MOE-rA(Bz)-3'-PS phosphoramidite for research workflows involving solid-phase oligonucleotide synthesis.
For N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite, mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- 2'-O-MOE-rA(Bz)-3'-PS phosphoramidite
- 5'-DMT-2'-O-MOE-A(Bz)-3'-PS phosphoramidite
- N6-Bz-5'-O-DMTr-2'-O-MOE-rA-3'-PS amidite
Useful catalog search terms
- CAS 2360826-72-6
Physicochemical data
| InChIKey | OKYFNXWXBWXJHI-QRWWDSLFSA-N |
|---|---|
| Nucleoside | Adenosine |
| Base protection | N6-Benzoyl |
| 5' protection | DMTr |
| 2'-Modification | O-Methoxyethyl (MOE) |
| 3'-functionality | S-(2-benzoylmercaptoethyl) pyrrolidino thiophosphoramidite |
| InChI | InChI=1S/C54H57N6O9PS2/c1-63-31-32-66-48-47(69-70(59-29-13-14-30-59)72-34-33-71-53(62)39-17-9-5-10-18-39)45(68-52(48)60-37-57-46-49(55-36-56-50(46)60)58-51(61)38-15-7-4-8-16-38)35-67-54(40-19-11-6-12-20-40,41-21-25-43(64-2)26-22-41)42-23-27-44(65-3)28-24-42/h4-12,15-28,36-37,45,47-48,52H,13-14,29-35H2,1-3H3,(H,55,56,58,61)/t45-,47-,48-,52-,70?/m1/s1 |
| SMILES | C(C1=CC=CC=C1)(SCCSP(N1CCCC1)O[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)N1C2=NC=NC(=C2N=C1)NC(C1=CC=CC=C1)=O)COC(C1=CC=CC=C1)(C1=CC=C(C=C1)OC)C1=CC=C(C=C1)OC)=O |
| Canonical SMILES | C(C1=CC=CC=C1)(SCCSP(N1CCCC1)O[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)N1C2=NC=NC(=C2N=C1)NC(C1=CC=CC=C1)=O)COC(C1=CC=CC=C1)(C1=CC=C(C=C1)OC)C1=CC=C(C=C1)OC)=O |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for N6-Benzoyl-5'-O-DMTr-2'-O-MOE-adenosine-3'-PS phosphoramidite be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-TP-0004 and CAS 2360826-72-6, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Thio Phosphoramidites product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.