Base-protected Nucleosides
2'-O-MOE-rC(Ac)
Quick view. N4-Acetyl cytidine bearing a 2'-O-(2-methoxyethyl) group and free 3'- and 5'-hydroxyl groups. CAS 2049081-09-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
2'-O-MOE-rC(Ac) is classified as base-protected nucleosides (Formula C14H21N3O7; molecular weight 343.34).
2'-O-MOE-rC(Ac) is relevant to high-stability antisense oligonucleotide gapmer and affinity-tuning research.
For 2'-O-MOE-rC(Ac), mOE placement needs design control, especially when RNase H recruitment or steric profile matters.
Names and search terms
Confirmed or normalized name variants
- N4-Acetyl-2'-O-(2-methoxyethyl)cytidine
- N4-Ac-2'-O-MOE-rC
- 2'-O-MOE-N4-Ac-cytidine
Useful catalog search terms
- CAS 2049081-09-4
Physicochemical data
| Nucleoside | Cytidine |
|---|---|
| Base protection | N4-acetyl |
| Sugar modification | 2'-O-(2-methoxyethyl) |
| Hydroxyl state | 3' and 5' hydroxyl groups unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-O-MOE motifs are often selected for enhanced nuclease resistance and improved duplex stability.
Method limitations
- MOE placement needs design control, especially when RNase H recruitment or steric profile matters.
These points describe 2'-O-MOE-rC(Ac) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 2'-O-MOE-rC(Ac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0084 and CAS 2049081-09-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the Base-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.