2'-F Nucleosides
(2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine
Quick view. We supply (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine as a 2'-fluoro nucleoside for modified nucleotide, amidite and nucleoside analog synthesis. CAS 863329-66-2. Catalog target purity: Specification on request.
Product profile
(2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine is classified as nucleoside or protected nucleoside intermediate (Formula C10H13FN2O5; molecular weight 260.219).
(2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
For (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine, reported solubility: DMSO (Slightly), Methanol (Slightly, Heated). Storage: Sealed in dry,Store in freezer, under -20°C.
Names and search terms
Confirmed or normalized name variants
- ro-2433
- CS-832
- PSI-6206
- 9-(2'
- 1-(2'
- GS-331007
- PSI 6206 int
- -deoxy-2'
Useful catalog search terms
- CAS 863329-66-2
- Nucleoside or protected nucleoside intermediate
- 2'-fluoro modification
- 2'-F Nucleosides
Physicochemical data
| Key chemistry motifs | 2'-fluoro modification |
|---|---|
| InChI | InChI=1S/C10H13FN2O5/c1-10(11)7(16)5(4-14)18-8(10)13-3-2-6(15)12-9(13)17/h2-3,5,7-8,14,16H,4H2,1H3,(H,12,15,17)/t5-,7-,8-,10-/m1/s |
| InChIKey | ARKKGZQTGXJVKW-VPCXQMTMSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@@](F)(C)[C@@H]1O |
| Melting point | 237-238℃ |
| Density | 1.55 |
| pKa | 9.39±0.10(Predicted) |
| Form | Solid |
| Color | White to Light Beige |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for (2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0209 and CAS 863329-66-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry.