2'-F Nucleosides
(2'R)-2'-Deoxy-2'-fluoro-2'-C-methyluridine
Quick view. A uridine derivative bearing 2'-fluoro and 2'-C-methyl sugar modifications, identified by CAS 863329-66-2. CAS 863329-66-2. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
(2'R)-2'-Deoxy-2'-fluoro-2'-C-methyluridine is classified as 2'-f nucleosides (Formula C10H13FN2O5; molecular weight 260.22).
(2'R)-2'-Deoxy-2'-fluoro-2'-C-methyluridine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For (2'R)-2'-Deoxy-2'-fluoro-2'-C-methyluridine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- GS-331007
- RO-2433
- PSI-6206
- (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine
Useful catalog search terms
- CAS 863329-66-2
- PubChem CID 11311503
- ARKKGZQTGXJVKW-VPCXQMTMSA-N
Physicochemical data
| InChIKey | ARKKGZQTGXJVKW-VPCXQMTMSA-N |
|---|---|
| NCATS UNII | 44V7045CXS |
| PubChem CID | 11311503 |
| Nucleoside scaffold | uridine |
| Sugar modifications | 2'-fluoro and 2'-C-methyl |
| Free hydroxyls | 3'-OH and 5'-OH |
| Stereochemistry | absolute; four defined stereocenters |
| InChI | InChI=1S/C10H13FN2O5/c1-10(11)7(16)5(4-14)18-8(10)13-3-2-6(15)12-9(13)17/h2-3,5,7-8,14,16H,4H2,1H3,(H,12,15,17)/t5-,7-,8-,10-/m1/s1 |
| SMILES | C[C@]1([C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O)F |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe (2'R)-2'-Deoxy-2'-fluoro-2'-C-methyluridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for (2'R)-2'-Deoxy-2'-fluoro-2'-C-methyluridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0209 and CAS 863329-66-2, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.