2'-F Nucleosides
4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine
Quick view. An unprotected uridine nucleoside bearing a 2'-fluoro-2',5'-dideoxy sugar and a 4',5'-exocyclic double bond, CAS 1365255-75-9. CAS 1365255-75-9. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine is classified as 2'-f nucleosides (Formula C9H9FN2O4; molecular weight 228.18).
4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine can be evaluated in chain-termination, sequencing-control or polymerase-specific substrate studies.
For 4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine, polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
Names and search terms
Confirmed or normalized name variants
- Uridine, 4',5'-didehydro-2',5'-dideoxy-2'-fluoro-
Useful catalog search terms
- CAS 1365255-75-9
- 1-[(2R,3R,4R)-3-fluoro-4-hydroxy-5-methylideneoxolan-2-yl]pyrimidine-2,4-dione
Physicochemical data
| Systematic name | 1-[(2R,3R,4R)-3-fluoro-4-hydroxy-5-methylideneoxolan-2-yl]pyrimidine-2,4-dione |
|---|---|
| SMILES | C=C1[C@H]([C@H]([C@@H](O1)N2C=CC(=O)NC2=O)F)O |
| Nucleobase | Uracil |
| Sugar modification | 2'-fluoro-2',5'-dideoxy |
| Unsaturation | 4',5'-didehydro (5'-methylene) |
| Hydroxyl protection | Unprotected 3'-hydroxyl |
| PubChem CID | 66802809 |
| InChIKey | RTZVNXFBDOQPGR-BWZBUEFSSA-N |
| InChI | InChI=1S/C9H9FN2O4/c1-4-7(14)6(10)8(16-4)12-3-2-5(13)11-9(12)15/h2-3,6-8,14H,1H2,(H,11,13,15)/t6-,7-,8-/m1/s1 |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- Dideoxy analogs provide clear extension-stop behavior when accepted by a polymerase.
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Polymerase acceptance varies; absence of a 3′-OH prevents further extension after incorporation.
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 4',5'-Didehydro-2',5'-dideoxy-2'-fluorouridine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0037 and CAS 1365255-75-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.