2'-F Nucleosides
5-Iodo-2'-fluoro-2'-deoxycytidine
Quick view. A cytidine nucleoside bearing a 5-iodo base substitution and a 2'-fluoro-2'-deoxy sugar modification, identified by CAS 80791-93-1. CAS 80791-93-1. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5-Iodo-2'-fluoro-2'-deoxycytidine is classified as 2'-f nucleosides (Formula C9H11FIN3O4; molecular weight 371.10).
5-Iodo-2'-fluoro-2'-deoxycytidine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5-Iodo-2'-fluoro-2'-deoxycytidine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-Deoxy-2'-fluoro-5-iodocytidine
Useful catalog search terms
- CAS 80791-93-1
- PubChem CID 5276642
Physicochemical data
| PubChem CID | 5276642 |
|---|---|
| InChIKey | GIMSJJHKKXRFGV-UAKXSSHOSA-N |
| Nucleoside scaffold | cytidine |
| Base modification | 5-iodo |
| Sugar modification | 2'-fluoro-2'-deoxy |
| Hydroxyl state | free 3' and 5' hydroxyls |
| InChI | InChI=1S/C9H11FIN3O4/c10-5-6(16)4(2-15)18-8(5)14-1-3(11)7(12)13-9(14)17/h1,4-6,8,15-16H,2H2,(H2,12,13,17)/t4-,5-,6-,8-/m1/s1 |
| SMILES | C1=C(C(=NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)F)N)I |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5-Iodo-2'-fluoro-2'-deoxycytidine or its named chemical feature. Broader product-family guidance is maintained on the category page.
Related products
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BX-MN-01822'-Deoxy-2'-fluorocytidine
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Frequently asked questions
Can the package size for 5-Iodo-2'-fluoro-2'-deoxycytidine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0203 and CAS 80791-93-1, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.