2'-F Nucleosides
5'-O-DMT-N2-DMF-2'-fluoro-2'-deoxyguanosine
Quick view. A protected 2'-fluoro-2'-deoxyguanosine bearing 5'-O-DMT and N2-DMF groups, CAS 1951424-82-0. CAS 1951424-82-0. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMT-N2-DMF-2'-fluoro-2'-deoxyguanosine is classified as 2'-f nucleosides (Formula C34H35FN6O6; molecular weight 642.68).
5'-O-DMT-N2-DMF-2'-fluoro-2'-deoxyguanosine is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5'-O-DMT-N2-DMF-2'-fluoro-2'-deoxyguanosine, coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- 2'-Deoxy-N2-DMF-5'-DMT-2'-fluoroguanosine
- 3D-ND177254
Useful catalog search terms
- CAS 1951424-82-0
- C34H35FN6O6
Physicochemical data
| Nucleobase | Guanine with N2-DMF protection |
|---|---|
| 5' protection | 5'-O-DMT |
| Sugar modification | 2'-Fluoro-2'-deoxy |
| Free hydroxyl | 3'-OH |
| Stereochemistry | Four assigned R stereocenters |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMT-N2-DMF-2'-fluoro-2'-deoxyguanosine or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMT-N2-DMF-2'-fluoro-2'-deoxyguanosine be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-2FN-0060 and CAS 1951424-82-0, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the 2'-F Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.