DMTr-protected Nucleosides
5'-O-DMTr-2'-F-dA(Bz)
Quick view. N6-Benzoyl-2'-fluoro-2'-deoxyadenosine bearing a 5'-O-DMTr group with a free 3'-hydroxyl group. CAS 136834-21-4. Catalog target purity: ≥98%. Availability: Inquiry only — contact BX Lab to confirm current availability.
Product profile
5'-O-DMTr-2'-F-dA(Bz) is classified as dmtr-protected nucleosides (Formula C38H34FN5O6; molecular weight 675.72).
5'-O-DMTr-2'-F-dA(Bz) is commonly assessed in siRNA, antisense and aptamer-style designs where ribose modification is used to tune stability and binding.
For 5'-O-DMTr-2'-F-dA(Bz), coupling, deprotection and biological performance remain sequence- and position-dependent.
Names and search terms
Confirmed or normalized name variants
- N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-fluoro-2'-deoxyadenosine
- DMT-2'-F-Bz-dA
Useful catalog search terms
- N6-Benzoyl-5'-O-DMTr-2'-fluoro-2'-deoxyadenosine
- CAS 136834-21-4
Physicochemical data
| Nucleoside | N6-Benzoyl-2'-fluoro-2'-deoxyadenosine |
|---|---|
| Hydroxyl protection | 5'-O-DMTr |
| Hydroxyl state | 3' hydroxyl group unprotected |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-F-dA(Bz) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-F-dA(Bz) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0064 and CAS 136834-21-4, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
These publications provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry. They are background reading only, not evidence for the exact product, supplied form, lot specification, availability or performance.
Technology platforms
Catalog-derived platform membership for navigating related chemistry and verifiable product sets.