DMTr-protected Nucleosides
5'-O-DMTr-2'-F-dC(Ac)
Quick view. We supply 5'-O-DMTr-2'-F-dC(Ac) as a DMTr-protected 2'-fluoro nucleoside intermediate for preparing 2'-F phosphoramidites, succinates or other oligonucleotide building blocks. CAS 159414-98-9. Catalog target purity: Specification on request.
Product profile
5'-O-DMTr-2'-F-dC(Ac) is classified as nucleoside or protected nucleoside intermediate (Formula C32H32FN3O7; molecular weight 589.61).
5'-O-DMTr-2'-F-dC(Ac) — N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide (CAS# 159414-98-9) is used in the preparation of solid supports for oligonucleotide syntheses which incorporate urea bridges.
For 5'-O-DMTr-2'-F-dC(Ac), reported solubility: DMSO: 250 mg/mL (424.01 mM; Need ultrasonic). Storage: 2-8°C.
Names and search terms
Confirmed or normalized name variants
- DMT-2'-F-dCAc
- DMT-2'-F-Ac-dC
- DMT-N4-Ac-2'-F-dC
- 5'-DMT-2'-F-Ac-dC
- N4-Ac-DMT-2'-F-dC
- 5'-O-DMT-N4-Ac-2'-F-dC
- 5'-O-DMT-2'-F-Acetyl-Deoxycytidine
- 5'-O-DMT-N4-acetyl-2'-Fluoro-2'-deoxycytidine
Useful catalog search terms
- CAS 159414-98-9
- Nucleoside or protected nucleoside intermediate
- DMTr/DMT protection
- 2'-fluoro modification
- DMTr-protected Nucleosides
Physicochemical data
| Key chemistry motifs | DMTr/DMT protection; 2'-fluoro modification |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| pKa | 10.12±0.20(Predicted) |
| Form | Solid |
| Color | White to off-white |
| SMILES | N1(C=CC(NC(C)=O)=NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2=CC=C(C=C2)OC)C2=CC=C(C=C2)OC)[C@@H](O)[C@H]1F |&1:11,13,39,41,r| |
| InChIKey | JIFNUYITABZZQS-VVRDZIKINA-N |
| InChI | InChI=1S/C32H32FN3O7/c1-20(37)34-27-17-18-36(31(39)35-27)30-28(33)29(38)26(43-30)19-42-32(21-7-5-4-6-8-21,22-9-13-24(40-2)14-10-22)23-11-15-25(41-3)16-12-23/h4-18,26,28-30,38H,19H2,1-3H3,(H,34,35,37,39)/t26-,28-,29-,30-/m1/s |
Release documentation
The current specification defines the analytical method and acceptance criteria; the released lot result is reported on the CoA.
Additional HPLC, MS or NMR documentation can be agreed during technical review where available.
Additional application examples
- 5'-O-DMTr-2'-F-dC(Ac) can serve as a starting material, protected intermediate or analytical comparator in nucleoside and nucleotide route development.
- Typical work includes protection/deprotection studies, phosphorylation or phosphitylation route scouting and impurity identification.
- The material can support medicinal-chemistry analog preparation and process-development feasibility studies.
Product-specific evaluation notes
Potential advantages
- 2′-fluoro motifs can improve nuclease resistance while preserving RNA-like geometry in many sequence contexts.
Method limitations
- Coupling, deprotection and biological performance remain sequence- and position-dependent.
These points describe 5'-O-DMTr-2'-F-dC(Ac) or its named chemical feature. Broader product-family guidance is maintained on the category page.
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Frequently asked questions
Can the package size for 5'-O-DMTr-2'-F-dC(Ac) be customized?
Yes. Share the initial quantity, expected future scale, delivery timeline and packaging preference for review.
What information should be included in a quote request?
Quote catalog number BX-PN-0062 and CAS 159414-98-9, the intended research workflow, required quantity and any additional HPLC, MS or NMR documentation needed.
Product-family literature
The publications below provide peer-reviewed context for the DMTr-protected Nucleosides product family and its named chemistry.